Article
Identification of fusion genes in breast cancer by paired-end RNA-sequencing.
Genome biology - 1 Jan 2011
Edgren Henrik, Murumagi Astrid, Kangaspeska Sara, Nicorici Daniel, Hongisto Vesa, Kleivi Kristine, Rye Inga H, Nyberg Sandra, Wolf Maija, Borresen-Dale Anne-Lise, Kallioniemi Olli
Abstract excerpt
BACKGROUND: Until recently, chromosomal translocations and fusion genes have been an underappreciated class of mutations in solid tumors. Next-generation sequencing technologies provide an opportunity for systematic characterization of cancer cell transcriptomes, including the discovery of expressed fusion genes resulting from underlying genomic rearrangements. RESULTS: We applied paired-end RNA-seq to identify...
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