Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology - 1 Jul 2012

Anwar Adil, Li Min, Frid Maria G, Kumar Binod, Gerasimovskaya Evgenia V, Riddle Suzette R, McKeon B Alexandre, Thukaram Roopa, Meyrick Barbara O, Fini Mehdi A, Stenmark Kurt R

Abstract excerpt

Increased cell proliferation and migration, of several cell types are key components of vascular remodeling observed in pulmonary hypertension (PH). Our previous data demonstrate that adventitial fibroblasts isolated from pulmonary arteries of chronically hypoxic hypertensive calves (termed PH-Fibs) exhibit a "constitutively activated" phenotype characterized by high proliferative and migratory potential....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Growth Processes
Share to Cell Hypoxia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hyaluronan Receptors

Share to Hypertension, Pulmonary

Share to Hypoxia

Share to Integrin alphaVbeta3

Share to Osteopontin

Share to Pulmonary Artery

Source

Open in PubMed Open full text

Identifiers

PMID: 22582113
DOI: 10.1152/ajplung.00050.2012
PMCID: PMC3426432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension.PMID 22582113Read ↗

Osteopontin aggravates myocardial fibrosis by promoting phenotypic transition of cardiac fibroblasts via Hippo-YAP pathway.Semantic proximity Read ↗

Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension.Semantic proximity Read ↗

Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells.Semantic proximity Read ↗

Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension.Semantic proximity Read ↗

Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells.Semantic proximity Read ↗

Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall.Semantic proximity Read ↗

Regulatory role for nucleosome assembly protein-1 in the proliferative and vasculogenic phenotype of pulmonary endothelium.Semantic proximity Read ↗

Paracrine Action of Bone Morphogenetic Protein 3 in Pulmonary Arterial HypertensionSemantic proximity Read ↗

The critical role of osteopontin (OPN) in fibrotic diseasesSemantic proximity Read ↗

MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts.Semantic proximity Read ↗

Human Aortic Valve Interstitial Cells Display Proangiogenic Properties During Calcific Aortic Valve Disease.Semantic proximity Read ↗

Osteopontin, a Key Mediator Expressed by Senescent Pulmonary Vascular Cells in Pulmonary Hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.