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Article

Roles of TGF-<i>β</i>Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis

1 Jan 2011

Abstract excerpt

Most cardiac diseases caused by inflammation are associated with fibrosis in the heart. Fibrosis is characterized by the accumulation of fibroblasts and excess deposition of extracellular matrix (ECM), which results in the distorted organ architecture and function. Recent studies revealed that cardiac fibroblasts are heterogeneous with multiple origins. Endothelial-mesenchymal transition (EndMT) plays important...

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Identifiers

PMID: 22187661
DOI: 10.4061/2011/724080

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