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Article

Impact of AGT rs5050(T>G) variants on associations between estradiol and angiotensinogen levels: Multi-Ethnic Study of Atherosclerosis (MESA).

PloS one - 1 Jan 2025

Lidani Karita C F, Trainor Patrick J, Tomar Shubham, Michos Erin D, Morgan Erin S, Rotter Jerome I, Guo Xiuqing, Tsimikas Sotirios, DeFilippis Andrew P

Abstract excerpt

AIMS: Angiotensinogen plays an essential role in maintaining circulatory homeostasis. AGT rs5050(T > G) has been identified as a regulator of the transcription of AGT mRNA, with differential expression between sexes. We sought to determine if rs5050(T > G), an estrogen response element, modifies the relationship between estrogen and angiotensinogen levels. METHODS: rs5050(T > G) was genotyped, and plasma...

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Identifiers

PMID: 41474705
DOI: 10.1371/journal.pone.0339786
PMCID: PMC12755761

Genes

AGT
TG

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