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Article

Testing for EGFR Variants in Pleural and Pericardial Effusion Cell-Free DNA in Patients With Non-Small Cell Lung Cancer.

JAMA oncology - 1 Feb 2023

Lee Kirsty W C, Li Molly S C, Gai Wanxia, Lau Yat Ming, Chan Allen K C, Chan Oscar S H, Lee Chee Khoon, Yeung Rebecca M W, Fung Sherwood Y H, Cheung Wai F, Chan Vivian W, Leung Linda, Kam Kenny N P, Mok Tony S K

Abstract excerpt

Importance: Molecular testing in non-small cell lung cancer (NSCLC) is commonly limited by inadequate tumor sample. Plasma cell-free DNA (cfDNA) genotyping as a complementary test is specific but only moderately sensitive. Genotyping of cfDNA in pleural and pericardial effusion (PE-cfDNA) can further optimize molecular diagnostic yield and reduce the need for repeated biopsies. Objective: To prospectively...

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Identifiers

PMID: 36580285
DOI: 10.1001/jamaoncol.2022.6109
PMCID: PMC9936333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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