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Article

Gtr9 mutation trades phage resistance for carbapenem sensitivity to potentiate phage-meropenem therapy against carbapenem-resistant Acinetobacter baumannii in vitro.

Antimicrobial agents and chemotherapy - 4 Feb 2026

Luo Jun, Liu Min, Ai Wen, Zheng Xiaoling, Han Lu, Huang Kuo, Zhang Changlin, Fan Jinhong, Li Qianyuan, Luo Chunhua

Abstract excerpt

The combined use of phages and antibiotics offers an alternative avenue against multidrug-resistant bacteria. We have previously described the synergistic antibacterial effect of the phage pB23 and meropenem combination against carbapenem-resistant Acinetobacter baumannii (CRAB). The study uncovers the underlying molecular mechanism of phage resistance in CRAB mediated by a novel stop-gain mutation in the gene...

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Identifiers

PMID: 41467804
DOI: 10.1128/aac.01355-25
PMCID: PMC12888894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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