Article

Engineered phages evade the complete defense repertoire of highly phage-resistant MRSA clinical isolates

2026-03-26

Abstract excerpt

Phage therapy is a re-emerging approach for antimicrobial-resistant bacterial infections. However, the narrow host range of most phages remains a major barrier to the success and wider adoption of phage therapy. Although receptor incompatibility is often assumed to define phage-host specificity, we demonstrate that anti-phage defense systems are major determinants of host range in Staphylococcus aureus . Using a...

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Literature Corpus work: 5e23f051-de1d-5d24-aa03-8cc4da5eea88
DOI: 10.64898/2026.03.26.714447

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