IFNL4-rs12979860 CC genotype predisposes to accelerated terminal exhaustion and senescence in HIV/HCV-chronic infection.

doi:10.1186/s12967-025-07070-5

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Article

IFNL4-rs12979860 CC genotype predisposes to accelerated terminal exhaustion and senescence in HIV/HCV-chronic infection.

Journal of translational medicine - 30 Dec 2025

Arca-Lafuente Sonia, Lara-Aguilar Violeta, Llamas-Adán Manuel, Grande-García Sergio, Deza de la Casa Andrés, Martín-Carbonero Luz, Ryan Pablo, de Los Santos Ignacio, Matarranz Mariano, Jiménez-Sousa Mª Ángeles, Fernández-Rodríguez Amanda, Briz Verónica

Abstract excerpt

PURPOSE: rs12979860 polymorphism of the lambda 4 interferon (IFNL4) gene has been related with Hepatitis C Virus (HCV) spontaneous clearance (CC genotype favourable versus CT/TT). The implications of this polymorphism over chronic-HCV disease are unknown, particularly during Human Immunodeficiency virus (HIV) coinfection. METHODS: Observational study in 118 people with HIV (PWH): 45 with HCV-chronic infection...

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PMID: 41466297
DOI: 10.1186/s12967-025-07070-5
PMCID: PMC12751784

Genes

CD4
CD38

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