Article
Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study.
BMC gastroenterology - 31 Dec 2019
So-Armah Kaku, Freiberg Matthew, Cheng Debbie, Lim Joseph K, Gnatienko Natalia, Patts Gregory, Doyle Margaret, Fuster Daniel, Lioznov Dmitry, Krupitsky Evgeny, Samet Jeffrey
Abstract excerpt
BACKGROUND: The multifactorial mechanisms driving negative health outcomes among risky drinkers with HIV may include immunosenescence. Immunosenescence, aging of the immune system, may be accentuated in HIV and leads to poor outcomes. The liver regulates innate immunity and adaptive immune tolerance. HIV-infected people have high prevalence of liver-related comorbidities. We hypothesize that advanced liver...
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