Low-level HIV-1 viremia affects T-cell activation and senescence in long-term treated adults in the INSTI era

Abstract excerpt

BACKGROUND: Around 10% of people with HIV (PWH) exhibit a low-level viremia (LLV) under antiretroviral therapy (ART). However, its origin and clinical significance are largely unknown, particularly at viremias between 50 and 200 copies/mL and under modern ART based on integrase strand transfer inhibitors (INSTIs). Our aim was to characterize their poor immune response against HIV in comparison to individuals with...

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• Cytomegalovirus and herpesvirus research
• HIV-related health complications and treatments
• HIV Research and Treatment