New candidate gene mutations in astrocytoma with seizures.

Abstract excerpt

Seizures are a common presenting symptom in astrocytomas, yet the underlying genomic drivers remain incompletely understood. We performed whole-exome sequencing on tumor tissue from 40 patients with astrocytoma (25 with preoperative seizures, 15 without) to explore somatic mutation profiles associated with seizure occurrence. Clinical characteristics, including age, tumor location, volume, and IDH mutation...

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