Article

The genomic landscape across 474 surgically accessible epileptogenic human brain lesions

2022-03-15

Abstract excerpt

Understanding the exact molecular mechanisms involved in the etiology of epileptogenic pathologies with or without tumor activity is essential for improving treatment of drug-resistant focal epilepsy. Here, we characterize the landscape of somatic genetic variants in resected brain specimens from 474 individuals with drug-resistant focal epilepsy using deep whole-exome sequencing (>350×) and whole-genome genotypin...

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Literature Corpus work: 8258ee15-46b0-5592-9d58-d67b7686b938
DOI: 10.1101/2022.03.14.22271705

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