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Transcriptional features of low-grade neuroepithelial tumors with the BRAF V600E mutation associated with epileptogenicity.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2024

Iijima Keiya, Komatsu Kanako, Miyashita Satoshi, Suyama Kyoka, Murayama Kumiko, Hashizume Koichi, Tabe Nao K, Miyata Hajime, Iwasaki Masaki, Taya Shinichiro, Hoshino Mikio

Abstract excerpt

Low-grade neuroepithelial tumors are major causes of drug-resistant focal epilepsy. Clinically, these tumors are defined as low-grade epilepsy-associated neuroepithelial tumors (LEATs). The BRAF V600E mutation is frequently observed in LEAT and linked to poor seizure outcomes. However, its molecular role in epileptogenicity remains elusive. To understand the molecular mechanism underlying the epileptogenicity in...

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PMID: 38269481
DOI: 10.1111/gtc.13096

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