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Article

Data-driven symptom dimensions reveal familial patterns in bipolar disorder.

Journal of affective disorders - 1 Apr 2026

Scott Katie, O'Donovan Claire, Meier Sandra, Pavlova Barbara, MacKinnon Dean F, Potash James B, Schulze Thomas G, Judy Jennifer, Zandi Peter P, Grof Paul, McMahon Francis J, Nunes Abraham, Alda Martin

Abstract excerpt

BACKGROUND: Bipolar disorder (BD) is a highly heritable psychiatric illness whose clinical and genetic heterogeneity complicates efforts to identify biologically-relevant subtypes. Traditional categorical approaches often fail to capture the multidimensional nature of BD symptomatology. This study aimed to evaluate whether data-driven dimensions show familial aggregation, suggesting potential genetic...

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Identifiers

PMID: 41461239
DOI: 10.1016/j.jad.2025.121060
PMCID: PMC13343236

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PC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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