Article
LspA-independent action of globomycin on Mycobacterium tuberculosis.
The Journal of antimicrobial chemotherapy - 1 Aug 2007
Banaiee Niaz, Jacobs William R, Ernst Joel D
Abstract excerpt
OBJECTIVES: The objective of this study was to investigate the antimicrobial activity and specificity of globomycin, an inhibitor of lipoprotein signal peptidase II (LspA), against Mycobacterium tuberculosis. METHODS: The mycobactericidal and mycobacteriostatic activity of globomycin was determined by optical density and cfu plating. The specificity of globomycin was determined by western immunoblotting using...
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