Article
Methicillin-resistant Staphylococcus aureus has phenotypic variation in mecA expression that alters antibiotic sensitivity.
Antimicrobial agents and chemotherapy - 4 Mar 2026
Ma Dongzhu, Arya Rekha, Knapick Beth Ann, Sadaka Nadine M, Rempuszewski Jewelia, Moul Claudette, Mandell Jonathan B, Shah Neel B, Doub James B, Gish Charles G, Parker Dana M, Parvizi Niosha, Sydlik Stefanie A, Wood Hunter B, Rokes Alecia B, Cooper Vaughn S, Richardson Anthony R, Shanks Robert M Q, Urish Kenneth L
Abstract excerpt
Methicillin resistant Staphylococcus aureus (MRSA) bacteremia has a high rate of morbidity and mortality. Multiple clinical studies have demonstrated improved outcomes when MRSA bacteremia is treated with dual antibiotic therapy that includes a β-lactam antibiotic such as cefazolin. This is a paradox as MRSA should be inherently resistant to this class of antibiotics. We report on a serendipitous observation of a...
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