Article
Massive reduction in methicillin resistance by transposon inactivation of the normal PBP2 in a methicillin-resistant strain of Staphylococcus aureus.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 1997
Pinho M G, Ludovice A M, Wu S, De Lencastre H
Abstract excerpt
Screening of a large transposon library constructed in the background of a highly and homogeneously methicillin-resistant Staphylococcus aureus (MRSA) strain (methicillin MIC 1,600 micrograms/ml) for Tn551 mutants with reduced resistance, identified mutant RUSA130 with a methicillin MIC of 12 mic...
Topics
- Bacterial Proteins
- Bacteriophages
- Carrier Proteins
- Culture Media
- DNA Transposable Elements
- DNA, Bacterial
- Hexosyltransferases
- Methicillin Resistance
- Muramoylpentapeptide Carboxypeptidase
- Mutation
- Penicillin-Binding Proteins
- Peptidyl Transferases
- Staphylococcus aureus
- Transduction, Genetic