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Article

Massive reduction in methicillin resistance by transposon inactivation of the normal PBP2 in a methicillin-resistant strain of Staphylococcus aureus.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 1997

Pinho M G, Ludovice A M, Wu S, De Lencastre H

Abstract excerpt

Screening of a large transposon library constructed in the background of a highly and homogeneously methicillin-resistant Staphylococcus aureus (MRSA) strain (methicillin MIC 1,600 micrograms/ml) for Tn551 mutants with reduced resistance, identified mutant RUSA130 with a methicillin MIC of 12 micrograms/ml. Cloning in E. coli followed by sequencing located the Tn551 insert omega 703 near the C-terminal of the...

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Identifiers

PMID: 9442495
DOI: 10.1089/mdr.1997.3.409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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