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Article

FOSL2+ macrophages drive pro-inflammatory phenotype via miR-92a-3p/FOSL2/NF-κB axis to mediate endothelial cell injury in aortic dissection.

Life sciences - 1 Mar 2026

Yuan Zhenpeng, Chen Ruihan, Fan Rong, Yang Zhenyu, Zhu Qianqian, Qiu Chenyang, Wu Ziheng, Li Donglin, He Yangyan, Zhang Hongkun

Abstract excerpt

BACKGROUND: In aortic dissection, macrophages play a critical role; however, the impact of macrophages on vascular endothelial cells remains unclear. METHODS: By constructing macrophage cell lines with stable overexpression and knockdown of FOSL2, M1 polarization was induced to evaluate the effects of FOSL2 on macrophage polarization, pro-inflammatory cytokine expression, macrophage migration, apoptosis, reactive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41453656
DOI: 10.1016/j.lfs.2025.124174

Genes

FOSL2
MYD88
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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