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Article

The GigaAssay: A combined high throughput and highly accurate platform for variant classification.

New biotechnology - 25 May 2026

Giacoletto Christopher J, Valente Liz J, Brown Lancer, Patterson Sara, Gokhale Rewatee, Mockus Susan M, Grody Wayne W, Deng Hong-Wen, Rotter Jerome I, Schiller Martin R

Abstract excerpt

ERBB2 (HER2) is a critical oncogene, yet the comprehensive and standardized assessment of its variant effects, particularly concerning receptor tyrosine kinase function, remains a major challenge. To compare the oncogenic potential of benchmark variants, we utilized the GigaAssay, a modular high-throughput one-pot assay system capable of simultaneously measuring their molecular function. We designed the GigaAssay...

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Share to Erb-b2 Receptor Tyrosine Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41448537
DOI: 10.1016/j.nbt.2025.12.001

Genes

ERBB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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