Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of deleterious nsSNP on the HER2 receptor based on stability and binding affinity with herceptin: a computational approach.

Comptes rendus biologies - 1 Jun 2008

Rajasekaran R, George Priya Doss C, Sudandiradoss C, Ramanathan K, Purohit Rituraj, Sethumadhavan Rao

Abstract excerpt

In this study, we identified the most deleterious non-synonymous SNP of ERBB2 (HER2) receptors by its stability and investigated its binding affinity with herceptin. Out of 135 SNPs, 10 are nsSNPs in the coding region, in which one of the nsSNP (SNPid rs4252633) is commonly found to be damaged by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Antibodies, Monoclonal, Humanized

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computational Biology

Share to Genes, erbB-2

Share to Hydrogen Bonding

Share to Models, Genetic

Share to Models, Molecular

Share to Trastuzumab

Source

Identifiers

PMID: 18510993
DOI: 10.1016/j.crvi.2008.03.004

Genes

ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18510993-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of deleterious nsSNP on the HER2 receptor based on stability and binding affinity with herceptin: a computational approach.PMID 18510993Read ↗

Enhanced computational strategies for categorizing HER2 kinase domain variants of uncertain significance through structural and functional analysis.Semantic proximity Read ↗

Computational and structural investigation of deleterious functional SNPs in breast cancer BRCA2 gene.Semantic proximity Read ↗

Investigating mutations at the hotspot position of the ERBB2 and screening for the novel lead compound to treat breast cancer - a computational approach.Semantic proximity Read ↗

Predicting the impact of deleterious mutations in the protein kinase domain of FGFR2 in the context of function, structure, and pathogenesis--a bioinformatics approach.Semantic proximity Read ↗

Predicting the most deleterious non-synonymous single nucleotide polymorphisms (nsSNPs) of HRAS gene and in silico evaluation of their structural and functional consequences towards diagnosis and prognosis of cancerSemantic proximity Read ↗

Identification of Damaging nsSNVs in HumanERCC2 Gene.Semantic proximity Read ↗

In silico analysis of structural and functional consequences in p16INK4A by deleterious nsSNPs associated CDKN2A gene in malignant melanoma.Semantic proximity Read ↗

Molecular characterization, homology modeling and docking studies of the R2787H missense variation in BRCA2 gene: Association with breast cancer.Semantic proximity Read ↗

Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects.Semantic proximity Read ↗

Structural investigation of deleterious non-synonymous SNPs of EGFR gene.Semantic proximity Read ↗

Computational Engineering of a Therapeutic Antibody to Inhibit Multiple Mutants of HER2 Without Compromising Inhibition of the Canonical HER2Semantic proximity Read ↗

A computational and structural approach to identify malignant non-synonymous FOXM1 single nucleotide polymorphisms in triple-negative breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.