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Article

Enhanced computational strategies for categorizing HER2 kinase domain variants of uncertain significance through structural and functional analysis.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2025

Loganathan Tamizhini, Doss C George Priya

Abstract excerpt

The HER2 (human epidermal growth factor receptor 2) kinase domain plays a pivotal role in receptor-mediated signaling and is frequently mutated across various cancer types. Variants of uncertain significance (VUS) within this domain pose significant challenges for clinical interpretation. In this study, a comprehensive computational analysis was conducted on 97 HER2 kinase domain variants comprising 25 pathogenic...

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PMID: 41073804
DOI: 10.1007/s00335-025-10165-5

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