Article

New Gain-of-Function Mutations Prioritize Mechanisms of HER2 Activation

2025-03-04

Abstract excerpt

ERBB2 (HER2) is a well-studied oncogene with several driver mutations apart from the well-known amplification defect in some breast cancers. We used the GigaAssay to test the functional effect of HER2 missense mutations on its receptor tyrosine kinase function. The GigaAssay is a modular high-throughput one-pot assay system for simultaneously measuring molecular function of thousands of genetic variants at very hi...

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Literature Corpus work: 9b32efae-0a9d-57bf-b163-b17ee142437b
DOI: 10.1101/2025.03.03.25323043

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