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Article

High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2018

Nagano Masaaki, Kohsaka Shinji, Ueno Toshihide, Kojima Shinya, Saka Kanju, Iwase Hirotaro, Kawazu Masahito, Mano Hiroyuki

Abstract excerpt

Purpose: The advent of next-generation sequencing technologies has enabled the identification of several activating mutations of Erb-B2 receptor tyrosine kinase 2 (ERBB2) among various cancers. However, the significance of infrequent mutations has not been fully investigated. Herein, we comprehensively assessed the functional significance of the ERBB2 mutations in a high-throughput manner.Experimental Design: We...

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Identifiers

PMID: 29967253
DOI: 10.1158/1078-0432.CCR-18-0991

Genes

ERBB2

Variants

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