Article
APOE epsilon 4 allele, cognitive dysfunction, and obstructive sleep apnea in children.
Neurology - 17 Jul 2007
Gozal David, Capdevila Oscar Sans, Kheirandish-Gozal Leila, Crabtree Valerie McLaughlin
Abstract excerpt
BACKGROUND: Obstructive sleep apnea (OSA) in children is associated with severity-dependent changes in neurocognitive functioning. However, the severity of OSA accounts for only approximately 40% of the variance in cognitive performance. Thus, genetic determinants of individual susceptibility may also contribute to the morbidity of OSA. Considering the unique susceptibility of apolipoprotein E (ApoE) knock-out...
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