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Article

Apolipoprotein-E4: risk of severe malaria and mortality and cognitive impairment in pediatric cerebral malaria.

Pediatric research - 1 Jul 2024

Lima-Cooper Giselle, Ouma Benson J, Datta Dibyadyuti, Bond Caitlin, Soto Alejandro A, Conroy Andrea L, Park Gregory S, Bangirana Paul, Joloba Moses L, Opoka Robert O, Idro Richard, John Chandy C

Abstract excerpt

BACKGROUND: The relationship of apolipoprotein-E4 (APOE4) to mortality and cognition after severe malaria in children is unknown. METHODS: APOE genotyping was performed in children with cerebral malaria (CM, n = 261), severe malarial anemia (SMA, n = 224) and community children (CC, n = 213). Cognition was assessed over 2-year follow-up. RESULTS: A greater proportion of children with CM or SMA than CC had APOE4...

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Identifiers

PMID: 38007518
DOI: 10.1038/s41390-023-02912-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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