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Article

Molecular Analysis of Mixed-Type and Branch-Duct Intraductal Papillary Mucinous Neoplasms.

JAMA surgery - 1 Feb 2026

Kannan Amudhan, Murimwa Gilbert Z, Mansour John C, Whitham Zachary A, Jones Alex R, Sheth Megha K, Abbas Ali, Deverakonda Abhi, Sawas Tarek, Ellis Daniel J, Vanderveldt Hendrikus S, Coleman Veronica, Foley Samantha, Tavakkoli Anna, Goldschmeidt Markus, Rajamohan Naveen, Khatri Gaurav, Brand Randall E, Nikiforova Marina N, Paniccia Alessandro, Zureikat Amer H, Lee Kenneth K W, Fleming Jason B, Zeh Herbert J, Kubiliun Nisa M, Singhi Aatur D, Polanco Patricio M

Abstract excerpt

Importance: Studying the molecular profiles of mixed-type and branch-duct (BD) intraductal papillary mucinous neoplasms (IPMNs) is important to understand the underlying biological basis for higher malignant potential of mixed-type IPMNs. Objective: To compare mutation patterns in mixed-type vs BD-IPMNs through cyst fluid next-generation sequencing (NGS) analysis using PancreaSeq NGS. Design, Setting, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41432930
DOI: 10.1001/jamasurg.2025.5692
PMCID: PMC12728731

Genes

SMAD4
TP53
CTNNB1
GNAS
KRAS
MTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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