Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization.

doi:10.1002/path.6437

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization.

The Journal of pathology - 1 Aug 2025

Pea Antonio, Bevere Michele, Gkountakos Anastasios, Pasini Davide, Fiorini Denise, Mafficini Andrea, Golovco Stela, Simbolo Michele, Pedron Serena, Sciammarella Concetta, Mattiolo Paola, Mombello Aldo, Villanova Manuela, Franzina Carlotta, Masetto Francesca, Ciulla Calogero, Sperandio Nicola, Fujikura Kohei, Ahadi Masha S, Samra Jaswinder S, Johns Amber L, Verheij Joanne, Stommel Martijn W J, van Santvoort Hjalmar, Schubert Santana Leonor, Malleo Giuseppe, Milella Michele, Brosens Lodewijk A A, Wood Laura D, Chang David K, De Robertis Riccardo, D'Onofrio Mirko, Gill Anthony J, Salvia Roberto, Corbo Vincenzo, Lawlor Rita T, Scarpa Aldo, Luchini Claudio

Abstract excerpt

Mucinous cystic neoplasms (MCNs) of the pancreas are macroscopic precursors of pancreatic cancer. A similar cystic lesion but lacking the ovarian-type subepithelial stroma has been recently defined as a simple mucinous cyst (SMC); however, its nature remains unclear. This study aims to define the clinicopathological and molecular profiles of a cohort of MCNs and SMCs of the pancreas and their associated invasive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Biomarkers, Tumor

Share to Carcinoma, Pancreatic Ductal

Share to Gene Expression Profiling

Share to Neoplasms, Cystic, Mucinous, and Serous

Share to Pancreatic Neoplasms

Share to Precancerous Conditions

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 40371932
DOI: 10.1002/path.6437
PMCID: PMC12256392

Genes

CDKN2A
KRAS
RNF43
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterizationPMID 40371932Read ↗

Simple mucinous cysts of the pancreas have heterogeneous somatic mutations.Semantic proximity Read ↗

Characterizing Biological Behavior Beyond Morphologic Features: Next-Generation Sequencing Analysis of Large vs Small Pancreatic Cystic Lesions in a Large Multicenter Cohort of Patients.Semantic proximity Read ↗

Molecular Analysis of Mixed-Type and Branch-Duct Intraductal Papillary Mucinous Neoplasms.Semantic proximity Read ↗

Molecular characterization of organoids derived from pancreatic intraductal papillary mucinous neoplasms.Semantic proximity Read ↗

Simple mucinous cyst: another potential cancer precursor in the pancreas? Case report with molecular characterization and systematic review of the literature.Semantic proximity Read ↗

Biomarkers in cystic lesions of the pancreas: Controversies and advances.Semantic proximity Read ↗

Genomic characterization of malignant progression in neoplastic pancreatic cysts.Semantic proximity Read ↗

Molecular Characterization of Pancreatic Simple Mucinous Cysts With GNAS Mutation: A Case Report and Literature Review.Semantic proximity Read ↗

Acinar Cystic Transformation of the PancreasSemantic proximity Read ↗

Intraductal Papillary Mucinous Carcinoma Versus Conventional Pancreatic Ductal Adenocarcinoma: A Comprehensive Review of Clinical-Pathological Features, Outcomes, and Molecular Insights.Semantic proximity Read ↗

Cytologic, histologic, and clinical correlation of minor mutations in pancreatic cysts.Semantic proximity Read ↗

Clinical utility of incorporating next-generation sequencing results in the management algorithm of pancreatic cysts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.