Article
Characterizing Biological Behavior Beyond Morphologic Features: Next-Generation Sequencing Analysis of Large vs Small Pancreatic Cystic Lesions in a Large Multicenter Cohort of Patients.
Journal of the American College of Surgeons - 1 Mar 2026
Kannan Amudhan, Murimwa Gilbert Z, Mansour John C, Whitham Zachary A, Zeh Herbert J, Kubiliun Nisa M, Singhi Aatur D, Polanco Patricio M
Abstract excerpt
BACKGROUND: Large pancreatic cystic lesions (PCLs) have a higher risk of malignant transformation compared with smaller PCLs, although the biological basis for this remains unclear. We aimed to study the high-risk mutation (HRM) patterns in large vs small PCLs using cyst fluid next-generation sequencing (NGS) analysis. STUDY DESIGN: This is a large multicenter study that included patients with PCLs who underwent...
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