Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MICA-129 Met/Met contributes to the susceptibility of colorectal cancer.

Medicine - 19 Dec 2025

Ye Jingxin, Chang Renan, Zhang Jianfeng, Qian Fei, Ding Weifeng

Abstract excerpt

The highly polymorphic human major histocompatibility complex class I chain-related gene A (MICA) regulates immune surveillance and destroys tumor cells by activating its receptor, the natural killer group 2D. This study aimed to examine a single nucleotide polymorphism of this gene at codon 129 (MICA-129) in association with colorectal cancer (CRC). Using PCR sequencing, the MICA-129 polymorphism was examined in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Biomarkers, Tumor
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Histocompatibility Antigens Class I

Share to Microsatellite Instability

Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins c-met

Source

Open in PubMed Open full text

Identifiers

PMID: 41431073
DOI: 10.1097/MD.0000000000046637
PMCID: PMC12727396

Genes

MICA
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MICA-129 Met/Met contributes to the susceptibility of colorectal cancer.PMID 41431073Read ↗

Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal CancerSemantic proximity Read ↗

MICA-129Met/Val Polymorphism Is Associated with Early-Onset Breast Cancer Risk.Semantic proximity Read ↗

Impact of the MICA-129Met/Val Dimorphism on NKG2D-Mediated Biological Functions and Disease RisksSemantic proximity Read ↗

Association between miR-27a genetic variants and susceptibility to colorectal cancer.Semantic proximity Read ↗

Association of CASP8 rs3834129 and CTGF rs6918698 genotypes with susceptibility to colorectal cancer in a Mexican population.Semantic proximity Read ↗

MICA-129 Met/Val polymorphism could be a genetic biomarker for Familial Breast Cancer in the Tunisian population.Semantic proximity Read ↗

The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantationSemantic proximity Read ↗

[Association of MICA gene polymorphism and serum soluble MICA level with colorectal cancer].Semantic proximity Read ↗

The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA.Semantic proximity Read ↗

Functional MICA-129 polymorphism and serum levels of soluble MICA are correlated with ulcerative colitis in Chinese patients.Semantic proximity Read ↗

Association of MICA-129 polymorphism with nasopharyngeal cancer risk in a Tunisian population.Semantic proximity Read ↗

[The relationship between major histocompatibility complex class I chain-related antigens A (MICA)-129 gene polymorphism, soluble MICA level and ulcerative colitis].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.