Article
Association between miR-27a genetic variants and susceptibility to colorectal cancer.
Diagnostic pathology - 30 Jul 2014
Wang Zaiqiu, Sun Xiaoli, Wang Yeli, Liu Xiaofang, Xuan Yuanjie, Hu Sanyuan
Abstract excerpt
BACKGROUND: MicroRNAs (miRNAs) are short, non-coding RNAs that negatively regulate target genes. A single nucleotide polymorphism (SNP) in a miRNA sequence may alter miRNA expression and/or maturation, which was proposed to associate with the development and progression of cancer. The rs895819 polymorphism, located in the terminal loop of pre-miR-27a, has been reported to have relevance to several cancers. In...
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