CCDC122-LACC1 gene polymorphism is associated with protection against leprosy in a population from Northeastern Brazil: a case-control study.

doi:10.1186/s12879-025-12391-3

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CCDC122-LACC1 gene polymorphism is associated with protection against leprosy in a population from Northeastern Brazil: a case-control study.

BMC infectious diseases - 22 Dec 2025

Freitas Heloisa de Almeida, Nogueira Karla Regina Celestino, Costa Allan Ribeiro Reis Scharf, Santos Luana Karen Correia Dos, Silva Ana Tércia Paulo, Oliveira Susana Paiva, Lima Vanderson Ferreira, Araújo Nathalí da Silva, Santos Walcelia Oliveira Dos, Pascoal Poliana Pinheiro, Valeriano José Karlison Tavares, Fraga Carlos Alberto de Carvalho, Souza Carlos Dornels Freire de, Barreto Emiliano de Oliveira, Figueiredo Elaine Virgínia Martins de Souza, Carmo Rodrigo Feliciano do, Sales-Marques Carolinne

Abstract excerpt

INTRODUCTION: Leprosy is a disease caused by Mycobacterium leprae and Mycobacterium lepromatosis, affecting the skin and peripheral nerves. In 2022, Brazil registered more than 19,000 new cases, considered a public health problem in the country. Interactions between the pathogen, host genetics, and the environment are factors to be considered for the development of leprosy. The CCDC122-LACC1 and IL23R genes play...

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Identifiers

PMID: 41430577
DOI: 10.1186/s12879-025-12391-3
PMCID: PMC12751134

Genes

LACC1
CCDC122
IL23R

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