Article
NOD2 and CCDC122-LACC1 genes are associated with leprosy susceptibility in Brazilians.
Human genetics - 1 Dec 2014
Sales-Marques Carolinne, Salomão Heloisa, Fava Vinicius Medeiros, Alvarado-Arnez Lucia Elena, Amaral Evaldo Pinheiro, Cardoso Cynthia Chester, Dias-Batista Ida Maria Foschiani, da Silva Weber Laurentino, Medeiros Priscila, da Cunha Lopes Virmond Marcos, Lana Francisco Carlos Félix, Pacheco Antonio Guilherme, Moraes Milton Ozório, Mira Marcelo Távora, Pereira Latini Ana Carla
Abstract excerpt
Leprosy is a complex disease with phenotypes strongly influenced by genetic variation. A Chinese genome-wide association study (GWAS) depicted novel genes and pathways associated with leprosy susceptibility, only partially replicated by independent studies in different ethnicities. Here, we describe the results of a validation and replication study of the Chinese GWAS in Brazilians, using a stepwise strategy that...
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