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Article

Adding immunotherapy to chemotherapy may improve survival after SCLC transformation in EGFR-mutant NSCLC: a multicenter real-world study.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2026

Demir Nazan, Kıkılı Cevat İlteriş, Kemik Fatih, Köylü Bahadır, Tural Deniz, Laçin Şahin, Gündüz Şeyda, Tunalı Didem, Mandel Nil Molinas, Yumuk Fulden, Inanc Mevlude, Cengiz Ayse Nuransoy, Uluç Başak Oyan, Ersoy Seval Ay, Busery Nisanur Sarıyar, Karakaya Serdar, Erdem Dilek, Akdoğan Orhun, Yazıcı Ozan, Kahraman Elanur, Bilgetekin İrem, Demirci Umut, Gür Hasibe Bilge, Ökten İlker Nihat, Karakaya Gökhan, Yıldız Oğuzhan, Eryılmaz Melek Karakurt, Canaslan Kübra, Seyyar Mustafa, Kaplan Muhammet Ali, Çubukçu Erdem, Akın Gül, Ersoy Mustafa, Sümbül Ahmet Taner, Özçelik Hakan, Özel Bozdağ Dilruba İlayda, Çiçek Ebru, Oflas Ülviye, Turkoz Fatma Paksoy, Garbioğlu Duygu Bayır, Selçukbiricik Fatih

Abstract excerpt

BACKGROUND: Histologic transformation to small-cell lung cancer (SCLC) is an aggressive resistance mechanism to EGFR tyrosine kinase inhibitor (TKI) therapy in EGFR-mutant non-small cell lung cancer (NSCLC). Real-world data on this population remain limited. METHODS: We conducted a multicenter retrospective cohort study across 26 oncology centers (2016-2025). Patients with histologically confirmed EGFR-mutant...

Read the complete abstract on PubMed

Topics

Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged

Female

Humans

Male

Middle Aged

Antineoplastic Combined Chemotherapy Protocols

Carcinoma, Non-Small-Cell Lung

Cell Transformation, Neoplastic

ErbB Receptors

Immunotherapy

Lung Neoplasms

Mutation

Protein Kinase Inhibitors

Retrospective Studies

Small Cell Lung Carcinoma

Lung

Source

Identifiers

PMID: 42664544
DOI: 10.1016/j.lungcan.2026.109590

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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