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Article

Potential therapeutic option for EGFR-mutant small cell lung cancer transformation: a case report and literature review.

Frontiers in immunology - 1 Jan 2024

Li Xiaoxuan, Luan Xinchi, Zhang Mengqi, Wang Rui, Guo Jing, Lv Jing, Qiu Wensheng, Zhao Shufen

Abstract excerpt

Transformation from non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) is rare and is associated with poor prognosis. However, the standard treatment protocols for patients with SCLC transformation remain unknown. Here, we report the case of a patient with advanced EGFR exon 19 deletion (19del) NSCLC who underwent SCLC transformation during targeted therapy. Biopsies and genetic testing were...

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Identifiers

PMID: 39234244
DOI: 10.3389/fimmu.2024.1439033
PMCID: PMC11371601

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