Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histologic transformation of epidermal growth factor receptor-mutated lung cancer.

European journal of cancer (Oxford, England : 1990) - 1 May 2022

Fujimoto Daichi, Akamatsu Hiroaki, Morimoto Takeshi, Wakuda Kazushige, Sato Yuki, Kawa Yoshitaka, Yokoyama Toshihide, Tamiya Motohiro, Hiraoka Ryota, Shingu Naoki, Ikeda Hideki, Tamiya Akihiro, Kanazu Masaki, Miyauchi Eisaku, Miura Satoru, Yanai Masaaki, Yomota Makiko, Morinaga Ryotaro, Yokoi Takashi, Hata Akito, Suzuki Hidekazu, Matsumoto Hirotaka, Sakata Shinya, Furuya Naoki, Harutani Yuhei, Nakachi Ichiro, Otsuki Ayumu, Uematsu Shinya, Hara Satoshi, Yokoo Keiki, Sugimoto Takeya, Yamamoto Nobuyuki

Abstract excerpt

PURPOSE: This study aimed to determine the incidence and clinical course of epidermal growth factor receptor (EGFR)-mutated lung cancer with histologic transformation (HT). PATIENTS AND METHODS: We conducted a multicentre, retrospective, cohort study of patients with advanced EGFR-mutated lung cancer who received EGFR-tyrosine kinase inhibitors (TKIs) between 2012 and 2019. The primary outcome was the incidence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Immune Checkpoint Inhibitors

Share to Lung Neoplasms

Share to Mutation

Share to Protein Kinase Inhibitors

Source

Identifiers

PMID: 35278824
DOI: 10.1016/j.ejca.2022.02.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histologic transformation of epidermal growth factor receptor-mutated lung cancer.PMID 35278824Read ↗

Histological transformation in lung cancer: a single-arm meta-analysis and systematic review.Semantic proximity Read ↗

Histological transformation after acquired resistance to epidermal growth factor tyrosine kinase inhibitors.Semantic proximity Read ↗

Clinicopathologic features and therapeutic outcomes in EGFR/ALK-aberrations NSCLC with histologic transformation.Semantic proximity Read ↗

Histological Transformation after Acquired Resistance to the Third-Generation EGFR-TKI in Patients with Advanced EGFR-Mutant Lung Adenocarcinoma.Semantic proximity Read ↗

Comprehensive molecular and clinical insights into non-small cell lung cancer transformation to small cell lung cancer with an illustrative case report.Semantic proximity Read ↗

Large Cell Neuroendocrine Carcinoma Transformation and EGFR-T790M Mutation as Coexisting Mechanisms of Acquired Resistance to EGFR-TKIs in Lung Cancer.Semantic proximity Read ↗

Genotyping of RB1 status identifies two distinct subtypes in EGFR ‐mutant lung cancers with SCLC transformationSemantic proximity Read ↗

Histologic transformation of non-small-cell lung cancer in response to tyrosine kinase inhibitors: Current knowledge of genetic changes and molecular mechanisms.Semantic proximity Read ↗

Small Cell Lung Cancer Transformation following Treatment in EGFR-Mutated Non-Small Cell Lung CancerSemantic proximity Read ↗

Histologic Transformation in EGFR-Mutant Lung Adenocarcinomas: Mechanisms and Therapeutic ImplicationsSemantic proximity Read ↗

Rare transformation from lung adenocarcinoma to sarcomatoid carcinoma mediates resistance to inhibitors targeting different driver oncogenesSemantic proximity Read ↗

Small cell lung cancer transformation after EGFR-TKIs treatment in lung adenocarcinoma: A case report and literatures review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.