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Article

Revisiting the impact of BRCA1 pathogenic variants on the aggressiveness of prostate cancer.

JNCI cancer spectrum - 9 Jan 2026

Sasagawa Hajime, Narita Shintaro, Matsuda Koichi, Kosaka Takeo, Momozawa Yukihide

Abstract excerpt

BRCA1 pathogenic variants are associated with a lower risk of developing prostate cancer than BRCA2, but aggressiveness remains unclear. Therefore, screening criteria are insufficiently established. Here, we reanalyzed the impact of BRCA1 pathogenic variants on aggressiveness using 11 300 prostate cancer patients, adjusting for age and area. The proportion of aggressive prostate cancer was higher in BRCA1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41423785
DOI: 10.1093/jncics/pkaf118
PMCID: PMC12803783

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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