Article
Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2010
Xu Jianfeng, Zheng Siqun Lilly, Isaacs Sarah D, Wiley Kathleen E, Wiklund Fredrik, Sun Jielin, Kader A Karim, Li Ge, Purcell Lina D, Kim Seong-Tae, Hsu Fang-Chi, Stattin Pär, Hugosson Jonas, Adolfsson Jan, Walsh Patrick C, Trent Jeffrey M, Duggan David, Carpten John, Grönberg Henrik, Isaacs William B
Abstract excerpt
Autopsy studies suggest that most aging men will develop lesions that, if detected clinically, would be diagnosed as prostate cancer (PCa). Most of these cancers are indolent and remain localized; however, a subset of PCa is aggressive and accounts for more than 27,000 deaths in the United States...
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