Article
Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms.
PloS one - 1 Jan 2015
Andreassen Ole A, Desikan Rahul S, Wang Yunpeng, Thompson Wesley K, Schork Andrew J, Zuber Verena, Doncheva Nadezhda T, Ellinghaus Eva, Albrecht Mario, Mattingsdal Morten, Franke Andre, Lie Benedicte A, Mills Ian G, Mills Ian, Aukrust Pål, McEvoy Linda K, Djurovic Srdjan, Karlsen Tom H, Dale Anders M
Abstract excerpt
Epidemiological studies suggest a relationship between blood lipids and immune-mediated diseases, but the nature of these associations is not well understood. We used genome-wide association studies (GWAS) to investigate shared single nucleotide polymorphisms (SNPs) between blood lipids and immune-mediated diseases. We analyzed data from GWAS (n~200,000 individuals), applying new False Discovery Rate (FDR)...
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