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Article

Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.

International journal of molecular sciences - 25 Feb 2026

Jiang Jianan, Peng Junhua, Li Lin, Xu Min

Abstract excerpt

Human preimplantation embryo arrest (PREMBA) represents a significant clinical hurdle in assisted reproductive technology (ART), in which approximately 10% of in vitro fertilized (IVF) embryos arrest at the cleavage stages. Whole-exome sequencing (WES) studies have discovered numerous genetic mutations associated with preimplantation embryo arrest. These mutations often disrupt critical biological milestones such...

Topics

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Blastocyst
Embryonic Development
Gene Expression Regulation, Developmental
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41828362
DOI: 10.3390/ijms27052135
PMCID: PMC12984818

Genes

TRIP13
BTG4
CDC20
CHEK1
DDOST
FBXO43
KHDC3L
KPNA7
MEI1
MEI4
MOS
NLRP2
NLRP5
NLRP7
OOEP
PADI6
REC114
TLE6
TOP6BL
TUBA4A
TUBB8
ZAR1
ZFP36L2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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