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Article

Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.

International journal of molecular sciences - 25 Feb 2026

Jiang Jianan, Peng Junhua, Li Lin, Xu Min

Abstract excerpt

Human preimplantation embryo arrest (PREMBA) represents a significant clinical hurdle in assisted reproductive technology (ART), in which approximately 10% of in vitro fertilized (IVF) embryos arrest at the cleavage stages. Whole-exome sequencing (WES) studies have discovered numerous genetic mutations associated with preimplantation embryo arrest. These mutations often disrupt critical biological milestones such...

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Identifiers

PMID: 41828362
DOI: 10.3390/ijms27052135
PMCID: PMC12984818

Genes

TRIP13
BTG4
CDC20
CHEK1
DDOST
FBXO43
KHDC3L
KPNA7
MEI1
MEI4
MOS
NLRP2
NLRP5
NLRP7
OOEP
PADI6
REC114
TLE6
TOP6BL
TUBA4A
TUBB8
ZAR1
ZFP36L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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