Article
Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs.
Current biology : CB - 2 Dec 2013
Pickrell Alicia M, Youle Richard J
Abstract excerpt
Mitochondrial diseases cause a range of clinical manifestations even in patients carrying the same mtDNA mutations. New work reveals that a common disease-associated mtDNA mutation is selectively segregated from wild-type mtDNA during the reprogramming of induced pluripotent stem cells and that high levels of this mutation in differentiated neurons upregulate Parkin-mediated mitophagy.
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