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Article

What Determines the Directionality of Kinesins? Studying the Anomalous Directionality of Nonclaret Disjunctional Motor Mutants.

Journal of the American Chemical Society - 14 Jan 2026

Halder Ritaban, Hu Linfeng, Warshel Arieh

Abstract excerpt

NCD (nonclaret disjunctional) motors are a class of kinesin family proteins that are known to walk toward the minus end along the microtubule. Understanding the origin of such unique directionality of NCD motors and related kinesins has been a problem of fundamental importance. Experimental studies have indicated that specific NCD motor mutants switch their directionality. A type of NCD mutant (ran12) walks in...

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Identifiers

PMID: 41414828
DOI: 10.1021/jacs.5c19758
PMCID: PMC13452579

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