Article
Decoupling of nucleotide- and microtubule-binding sites in a kinesin mutant.
Nature - 10 Dec 1998
Song H, Endow S A
Abstract excerpt
Molecular motors require ATP to move along microtubules or actin filaments. To understand how molecular motors function, it is crucial to know how binding of the motor to its filamentous track stimulates the hydrolysis of ATP by the motor, enabling it to move along the filament. A mechanism for the enhanced ATP hydrolysis has not been elucidated, but it is generally accepted that conformational changes in the...
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