Article

Neck-region–microtubule interactions direct counterclockwise stepping of kinesin-1

2025-06-09

Abstract excerpt

The “neck” region of kinesin is a structurally conserved element critical for force generation, stepping directionality, and cargo transport along microtubules, yet its atomic-scale structure in a functional context remains unresolved. Here, we employ all-atom replica exchange molecular dynamics simulations to resolve a high-confidence conformation of the neck region in dimeric human kinesin-1 bound to a realistic...

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Identifiers and source

Literature Corpus work: 8d95fb8c-ef5b-599e-9c35-e9652836f900
DOI: 10.1101/2025.06.07.658466

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