A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd.

doi:10.1038/nature04320

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Article

A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd.

Nature - 16 Feb 2006

Endres Nicholas F, Yoshioka Craig, Milligan Ronald A, Vale Ronald D

Abstract excerpt

Kinesins are microtubule-based motor proteins that power intracellular transport. Most kinesin motors, exemplified by Kinesin-1, move towards the microtubule plus end, and the structural changes that govern this directional preference have been described. By contrast, the nature and timing of the structural changes underlying the minus-end-directed motility of Kinesin-14 motors (such as Drosophila Ncd) are less...

Topics

Adenosine Triphosphate
Animals
Cryoelectron Microscopy
Drosophila Proteins
Kinesins
Microtubules
Models, Biological
Models, Molecular
Mutation
Protein Conformation
Rotation
Structure-Activity Relationship

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Identifiers

PMID: 16382238
DOI: 10.1038/nature04320
PMCID: PMC2851630

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