Article
A Multimodal Ensemble Framework for Optimal Mutant Prediction and Computational Enzyme Engineering.
Angewandte Chemie (International ed. in English) - 2 Feb 2026
Luo Ding, Ji Huining, Hu Baodong, Cai Jinxing, Wen Kaiqi, Qu Xiaoyang, Cao Mingfeng, Zhao Xinrui, Wang Binju
Abstract excerpt
Exploring mutational landscape of proteins to engineer improved enzymes remains a fundamental challenge. Traditional methods, whether reliant on high-throughput experimentation, direct evolution, or on computational prediction, often face challenges to effectively model the complex epistatic and long-range interactions that related to protein function. To address this, we present GEMS, a robust framework for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.