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EvoZymePro-Cat: A Protein-Ligand-Aware Deep Learning Framework for Predicting Mutation Effects in Enzyme Function.

ACS synthetic biology - 16 Jan 2026

Xu Ran, Li Xinkang, Sui Jianan, Wu Lei, Ling Chen, Zheng Liangzhen, Guo Jingjing

Abstract excerpt

Enzymes are biological catalysts that speed up chemical reactions in an eco-friendly way. Precise enzyme design is hindered by vast sequence space and intricate sequence-structure-function interdependencies. To address these challenges, we developed EvoZymePro-Cat (EZPro-Cat), a deep learning platform for enzyme mutant screening. Conventional methods for predicting absolute mutant activities suffer from...

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Deep Learning
Enzymes
Ligands
Mutation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41422407
DOI: 10.1021/acssynbio.5c00755

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