Article
Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering.
Cell research - 1 Sept 2024
Cheng Peng, Mao Cong, Tang Jin, Yang Sen, Cheng Yu, Wang Wuke, Gu Qiuxi, Han Wei, Chen Hao, Li Sihan, Chen Yaofeng, Zhou Jianglin, Li Wuju, Pan Aimin, Zhao Suwen, Huang Xingxu, Zhu Shiqiang, Zhang Jun, Shu Wenjie, Wang Shengqi
Abstract excerpt
Mutations in amino acid sequences can provoke changes in protein function. Accurate and unsupervised prediction of mutation effects is critical in biotechnology and biomedicine, but remains a fundamental challenge. To resolve this challenge, here we present Protein Mutational Effect Predictor (ProMEP), a general and multiple sequence alignment-free method that enables zero-shot prediction of mutation effects. A...
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