EnzyACT: A Novel Deep Learning Method to Predict the Impacts of Single and Multiple Mutations on Enzyme Activity.

Abstract excerpt

Enzyme engineering involves the customization of enzymes by introducing mutations to expand the application scope of natural enzymes. One limitation of that is the complex interaction between two key properties, activity and stability, where the enhancement of one often leads to the reduction of the other, also called the trade-off mechanism. Although dozens of methods that predict the change of protein stability...

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