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Article

Multilayered Regulatory Dynamics of p53 Mutations and Platinum Resistance in Ovarian Cancer.

Journal of proteome research - 2 Jan 2026

Hu Liling, Zou Hanchen, Peng LvYing, Li Fan, Liu Danya, Lu Jiangli, Li Yuying, Zhang Chris Zhiyi, Tian Qiu-Hong

Abstract excerpt

TP53 mutation-driven gene expression programs define oncogenic phenotypes. While extensive studies have concentrated on the transcriptome and proteome, post-transcriptional processes, particularly translational variation, remain underexplored. This study presents a comprehensive analysis of the transcriptomics, translatiomics, and proteomics dynamics in the ovarian cancer cell line SKOV3, with a focus on the...

Topics

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Drug Resistance, Neoplasm
Gene Expression Regulation, Neoplastic
Mutation, Missense
Ovarian Neoplasms
Platinum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

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Identifiers

PMID: 41400635
DOI: 10.1021/acs.jproteome.5c00657

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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