Back to search

Article

Novel regulatory and transcriptional networks associated with resistance to platinum-based chemotherapy in ovarian cancer

2020-09-10

Abstract excerpt

<h4>Background</h4> High-grade serous ovarian cancer (HGSOC) is a highly lethal gynecologic cancer, in part due to resistance to platinum-based chemotherapy reported among 20% of patients. This study aims to elucidate the biological mechanisms underlying chemotherapy resistance, which remain poorly understood. <h4>Methods</h4> Sequencing data (mRNA and microRNA) from HGSOC patients were analyzed to identify diff...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5be21176-3467-53e7-bb89-1c161781d836
DOI
10.1101/2020.09.09.289868
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Novel regulatory and transcriptional networks associated with resistance to platinum-based chemotherapy in ovarian cancerDOI 10.1101/2020.09.09.289868
MicroRNA-Regulated Ubiquitination and Lipid Metabolism Networks are Associated with Chemotherapy Response in Ovarian CancerSemantic proximity
Gene networks and expression quantitative trait loci associated with platinum-based chemotherapy response in high-grade serous ovarian cancerSemantic proximity
Gene networks and expression quantitative trait loci associated with platinum-based chemotherapy response in high-grade serous ovarian cancerSemantic proximity
Identification of platinum-resistance related small GTPase binding signatures to predict the prognosis of ovarian cancer by machine learning and integrated bioinformatic analysesSemantic proximity
Angiogenic mRNA and microRNA Gene Expression Signature Predicts a Novel Subtype of Serous Ovarian CancerSemantic proximity
Neoadjuvant Chemotherapy Modulates the Tumor Microenvironment in High-Grade Serous Ovarian CancerSemantic proximity
Does neoadjuvant chemotherapy bias the transcriptomic profile of platinum-sensitive advanced high grade serous ovarian cancer patients towards a resistant phenotype? Findings from a gene expression meta-analysisSemantic proximity
A Novel Platinum Resistance-related Immune Gene Signature for Overall Survival Prediction in Patients with Ovarian CancerSemantic proximity
Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first-line platinum chemotherapy in high grade serous ovarian cancer.Semantic proximity
Gene Expression Profiles in Ovarian Cancer Tissues as a Potential Tool to Predict Platinum-based Chemotherapy ResistanceSemantic proximity
Leveraging Genomics, Transcriptomics, and Epigenomics to Understand the Biology and Chemoresistance of Ovarian CancerSemantic proximity
Development and Validation of an Immune-Related Gene-Pair Model of High-Grade Serous Ovarian Cancer After Platinum-Based ChemotherapySemantic proximity
Select a neighboring publication to make it the new centre.